Primary efficacy endpoint: early clinical response

A single 30 minute infusion of Xydalba is as effective as treatment with vancomycin/linezolid at 48-72hrs8

Graph showing Early Clinical Response* at 48-72 Hours in the ITT Population

*Early clinical response was defined as both cessation of spread of the erythema associated with the infection and a temperature of 37.6 °C or lower at three consecutive readings performed 6 hours apart at 48-72 hours in the ITT population

DISCOVER 1 Absolute Difference (95% CI) Percentage Points [1.5 (–4.6 to 7.9)]. DISCOVER 2 Absolute Difference (95% CI) Percentage Points [-1.5 (–7.4, 4.6)]. Pooled Analysis Absolute Difference (95% CI) Percentage Points [-0.1 (–4.5 to 4.2)].

8 Boucher HW, et al. N Engl J Med. 2014;370:2169-79.